Quazepam

Generic Name: quazepam (KWAY ze pam)

Brand Names: Doral

What is quazepam?

Quazepam is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Quazepam affects chemicals in the brain that may become unbalanced and cause sleep problems (insomnia).

Quazepam is used to treat insomnia symptoms, such as trouble falling or staying asleep.

Quazepam may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about quazepam?

Quazepam may cause a severe allergic reaction. Stop taking quazepam and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Take quazepam only when you are getting ready for several hours of sleep. You may fall asleep very quickly after taking the medicine.

Some people using this medicine have engaged in activity such as driving, eating, or making phone calls and later having no memory of the activity. If this happens to you, stop taking quazepam and talk with your doctor about another treatment for your sleep disorder.

Do not use this medication if you are allergic to quazepam or to other benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), midazolam (Versed), temazepam (Restoril), or triazolam (Halcion). This medication can cause birth defects in an unborn baby, or withdrawal symptoms in a newborn. Do not use quazepam if you are pregnant.

Before taking quazepam, tell your doctor if you have any breathing problems, kidney or liver disease, or a history of depression, mental illness, suicidal thoughts, or addiction to drugs or alcohol.

Quazepam may be habit-forming and should be used only by the person it was prescribed for. Quazepam should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Quazepam should be used for only a short time to treat insomnia. After 7 to 10 nights of use, talk with your doctor about whether or not you should keep taking quazepam.

What should I discuss with my healthcare provider before taking quazepam?

Some people using this medicine have engaged in activity such as driving, eating, or making phone calls and later having no memory of the activity. If this happens to you, stop taking quazepam and talk with your doctor about another treatment for your sleep disorder.

Do not use this medication if you are allergic to quazepam or to other benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), midazolam (Versed), temazepam (Restoril), or triazolam (Halcion).

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take quazepam.

• 
  

  asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;

  
  


• 
  

  kidney or liver disease;

  
  


• 
  

  a history of depression, mental illness, suicidal thoughts or behavior; or

  
  


• 
  

  a history of drug or alcohol addiction.

  
  

FDA pregnancy category X. Quazepam can cause birth defects in an unborn baby. It may also cause withdrawal symptoms in a newborn if the mother takes quazepam during pregnancy. Do not use quazepam if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. Quazepam can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

The sedative effects of quazepam may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking quazepam.

Do not give this medication to anyone under 18 years old.

How should I take quazepam?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take quazepam only when you are getting ready for several hours of sleep. You may fall asleep very quickly after taking the medicine. Do not take quazepam with food or just after a meal. Contact your doctor if this medicine seems to stop working as well in helping you fall asleep and stay asleep. Quazepam should be used for only a short time to treat insomnia. After 7 to 10 nights of use, talk with your doctor about whether or not you should keep taking quazepam. Do not take this medication for longer than 12 weeks without your doctor's advice.

Your insomnia symptoms may return when you stop using quazepam, especially during the first day or two. You may also have unpleasant withdrawal symptoms such as vomiting, stomach pain, muscle cramps, sweating, shaky or unpleasant feeling, or seizure (convulsions). Talk to your doctor about how to avoid withdrawal symptoms when you stop using quazepam.

Quazepam may be habit-forming and should be used only by the person it was prescribed for. Quazepam should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Store quazepam at room temperature away from moisture, heat, and light.

Keep track of how many tablets have been used from each new bottle of this medicine. Benzodiazepines are drugs of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

See also: Quazepam dosage (in more detail)

What happens if I miss a dose?

Since quazepam is taken as needed, you are not likely to be on a dosing schedule. Take quazepam only when you have time for several hours of sleep.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of quazepam can be fatal, especially if you take it with alcohol.

Overdose symptoms may include extreme drowsiness, confusion, and fainting or coma.

What should I avoid while taking quazepam?

Do not drink alcohol while taking quazepam. Even alcohol consumed during the day can increase the side effects of quazepam taken at bedtime. Avoid alcohol for several days after taking quazepam, as small amounts of the drug may remain in your body during that time. Quazepam can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Quazepam side effects

Quazepam may cause a severe allergic reaction. Stop taking quazepam and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using quazepam and call your doctor at once if you have a serious side effect such as:

• 
  

  worsening insomnia;

  
  


• 
  

  confusion, anxiety, slurred speech, unusual thoughts or behavior;

  
  


• 
  

  hallucinations, agitation, aggression;

  
  


• 
  

  weak or shallow breathing;

  
  


• 
  

  fast or pounding heartbeats;

  
  


• 
  

  muscle stiffness in your tongue, jaw, or neck;

  
  


• 
  

  problems with urination; or

  
  


• 
  

  jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects may include:

• 
  

  daytime drowsiness (or during hours when you are not normally sleeping);

  
  


• 
  

  amnesia or forgetfulness;

  
  


• 
  

  muscle weakness, lack of balance or coordination;

  
  


• 
  

  dizziness, vision problems;

  
  


• 
  

  nightmares;

  
  


• 
  

  headache, blurred vision, depressed mood;

  
  


• 
  

  feeling nervous, excited, or irritable;

  
  


• 
  

  impotence, loss of interest in sex;

  
  


• 
  

  mild itching or skin rash;

  
  


• 
  

  nausea, diarrhea, stomach pain, loss of appetite; or

  
  


• 
  

  dry mouth, increased thirst.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Quazepam Dosing Information

Usual Adult Dose for Insomnia:

15 mg orally before retiring.
The dose may then be reduced to 7.5 mg in some patients.

What other drugs will affect quazepam?

Cold or allergy medicine, sedatives, narcotic pain medicine, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by quazepam. Tell your doctor if you regularly use any of these medicines, or any other sleep medication.

Tell your doctor about all other medications you use, especially:

• 
  

  bupropion (Wellbutrin, Zyban);

  
  


• 
  

  cyclophosphamide (Cytoxan, Neosar);

  
  


• 
  

  efavirenz (Sustiva);

  
  


• 
  

  irinotecan (Camptosar);

  
  


• 
  

  promethazine (Phenergan); or

  
  


• 
  

  selegiline (Eldepryl, Emsam, Zelapar).

  
  

This list is not complete and there may be other drugs that can interact with quazepam. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More quazepam resources

• Quazepam Side Effects (in more detail)
• Quazepam Dosage
• Quazepam Use in Pregnancy & Breastfeeding
• Quazepam Drug Interactions
• Quazepam Support Group
• 1 Review for Quazepam - Add your own review/rating

• quazepam Advanced Consumer (Micromedex) - Includes Dosage Information


• Quazepam Professional Patient Advice (Wolters Kluwer)


• Quazepam MedFacts Consumer Leaflet (Wolters Kluwer)

Compare quazepam with other medications

• Insomnia

Where can I get more information?

• Your pharmacist can provide more information about quazepam.

See also: quazepam side effects (in more detail)

Refacto recombinant

Generic Name: antihemophilic factor (recombinant) (ant ee hee moe FIL ik FAK tor (ree KOM bin ant))

Brand Names: Advate rAHF-PFM, Helixate FS, Kogenate FS, Kogenate FS with Bioset, Recombinate, Refacto, Xyntha, Xyntha Solofuse

What is recombinant antihemophilic factor?

Antihemophilic factor is a naturally occurring protein in the blood that helps blood to clot. A lack of antihemophilic factor VIII is the cause of hemophilia A.

This medication works by temporarily raising levels of factor VIII in the blood to aid in clotting.

Recombinant antihemophilic factor is used to treat or prevent bleeding episodes in adults and children with hemophilia A. It is also used to control bleeding related to surgery or dentistry in a person with hemophilia, and to prevent joint damage in people age 16 or older with severe hemophilia A and no prior joint damage.

Recombinant antihemophilic factor is not for use in people with von Willebrand disease.

Recombinant antihemophilic factor may also be used for purposes not listed in this medication guide.

What is the most important information I should know about recombinant antihemophilic factor?

Do not use this medication if you have ever had a severe allergic reaction to antihemophilic factor in the past, or if you are allergic to mouse or beef proteins.

Before using recombinant antihemophilic factor, your specific blood clotting disorder must be diagnosed as factor VIII deficiency. Human antihemophilic factor will not treat von Willebrand disease.

Your body may develop antibodies to this medication, making it less effective. Call your doctor if this medicine seems to be less effective in controlling your bleeding.

To be sure this medication is helping your condition and is not causing harmful effects, your blood may need to be tested often. Visit your doctor regularly.

Wear a medical alert tag or carry an ID card stating that you have hemophilia. Any doctor, dentist, or emergency medical care provider who treats you should know that you have a bleeding or blood-clotting disorder.

What should I discuss with my health care provider before using recombinant antihemophilic factor?

Do not use this medication if you have ever had a severe allergic reaction to antihemophilic factor in the past, or if you are allergic to mouse or beef proteins.

Before using recombinant antihemophilic factor, your specific blood clotting disorder must be diagnosed as factor VIII deficiency. Recombinant antihemophilic factor will not treat von Willebrand disease.

FDA pregnancy category C. It is not known whether recombinant antihemophilic factor will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether recombinant antihemophilic factor passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use recombinant antihemophilic factor?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Always check the strength of the medicine on the label to be sure you are using the correct potency.

Recombinant antihemophilic factor is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Always wash your hands before preparing and giving your injection.

Recombinant antihemophilic factor must be mixed with a liquid (diluent) before injecting it. If you store your medicine in the refrigerator, take a medicine and diluent vial out of the refrigerator and allow each to reach room temperature before mixing them.

Gently swirl the medicine and diluent to mix them and allow the medicine to completely dissolve.

After mixing the medicine and diluent, the mixture should be kept at room temperature and must be used within 3 hours. Do not put mixed medicine into the refrigerator.

Prepare your dose in a syringe only when you are ready to give yourself an injection. Each vial is for one use only. After measuring your dose, throw the vial away, even if there is medicine left in it.

Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Recombinant antihemophilic factor is usually given every 8 to 24 hours for 1 to 4 days, depending on the reason you are using the medication.

To be sure this medication is helping your condition and is not causing harmful effects, your blood may need to be tested often. Visit your doctor regularly.

Your body may develop antibodies to antihemophilic factor, making it less effective. Call your doctor if this medicine seems to be less effective in controlling your bleeding.

Wear a medical alert tag or carry an ID card stating that you have hemophilia. Any doctor, dentist, or emergency medical care provider who treats you should know that you have a bleeding or blood-clotting disorder. Store the medication and the diluent in the refrigerator and do not allow them to freeze. You may also store the medication and diluent at room temperature until the expiration date on the label. Some brands of this medicine can be stored at room temperature for only a certain number of months, or until the expiration date (whichever comes first). Follow the storage directions on the medicine label.

Do not store this medicine in bright light. Throw away any leftover medicine and diluent if the expiration date has passed.

What happens if I miss a dose?

Recombinant antihemophilic factor is sometimes used only as needed, so you may not be on a dosing schedule. If you are taking the medication regularly, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using recombinant antihemophilic factor?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Recombinant antihemophilic factor side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; feeling light-headed, fainting; swelling of your face, lips, tongue, or throat. Stop using recombinant antihemophilic factor and call your doctor at once if you have a serious side effect such as:

• 
  

  chest pain;

  
  


• 
  

  easy bruising, increased bleeding episodes; or

  
  


• 
  

  bleeding from a wound or where the medicine was injected.

  
  

Less serious side effects may include:

• 
  

  sore throat, cough, runny nose;

  
  


• 
  

  fever or chills;

  
  


• 
  

  mild nausea, vomiting;

  
  


• 
  

  unusual or unpleasant taste in your mouth;

  
  


• 
  

  skin itching or rash;

  
  


• 
  

  warmth, redness, itching, or tingling under your skin;

  
  


• 
  

  joint pain or swelling;

  
  


• 
  

  dizziness;

  
  


• 
  

  headache; or

  
  


• 
  

  swelling, stinging, or irritation where the injection was given.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect recombinant antihemophilic factor?

There may be other drugs that can interact with recombinant antihemophilic factor. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Refacto resources

• Refacto Side Effects (in more detail)
• Refacto Use in Pregnancy & Breastfeeding
• Refacto Support Group
• 0 Reviews for Refacto - Add your own review/rating

Compare Refacto with other medications

• Hemophilia A

Where can I get more information?

• Your pharmacist can provide more information about recombinant antihemophilic factor.

See also: Refacto side effects (in more detail)

Cytotec

Generic Name: misoprostol (Oral route)

mye-soe-PROST-ol

Oral route(Tablet)

Administration of misoprostol to women who are pregnant can cause abortion, premature birth, or birth defects. Uterine rupture has been reported when misoprostol was administered in pregnant women to induce labor or to induce abortion beyond the eighth week of pregnancy. Misoprostol should not be used for reducing the risk of NSAID-induced ulcers in women of childbearing potential unless the patient is at high risk of developing gastric ulcers or complications. Women must have a negative serum pregnancy test within 2 weeks prior to beginning therapy and effective contraceptive measures must be used. Oral and written warnings of the hazards of misoprostol, including the risk of possible contraception failure, must be given to the patient prior to initiating therapy .

Commonly used brand name(s)

In the U.S.

• Cytotec

Available Dosage Forms:

• Tablet

Therapeutic Class: Endocrine-Metabolic Agent

Pharmacologic Class: Prostaglandin

Uses For Cytotec

Misoprostol is taken to prevent stomach ulcers in patients taking anti-inflammatory drugs, including aspirin. Misoprostol may also be used for other conditions as determined by your doctor.

Misoprostol helps the stomach protect itself against acid damage. It also decreases the amount of acid produced by the stomach.

This medicine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, misoprostol may be used in certain patients with the following medical conditions:

• Abortion, first trimester


• Abortion, second trimester


• Cervical ripening


• Induction of labor


• Postpartum hemorrhage

Before Using Cytotec

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of misoprostol in children with use in other age groups.

Geriatric

This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	X	Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Phenylbutazone

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Blood vessel disease—Medicines similar to misoprostol have been shown to make this condition worse

• Epilepsy (uncontrolled)—Medicines similar to misoprostol have been shown to cause convulsions (seizures)


• Inflammatory bowel disease—Misoprostol may worsen diarrhea, which could lead to dehydration

Proper Use of Cytotec

Misoprostol is best taken with or after meals and at bedtime, unless otherwise directed by your doctor. To help prevent loose stools, diarrhea, and abdominal cramping, always take this medicine with food or milk.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• To prevent stomach ulcers in patients taking anti-inflammatory medicines including aspirin:
  
  • For oral dosage form (tablets):
    
    • Adults—200 micrograms (mcg) four times a day, with or after meals and at bedtime. Or, your dose may be 400 mcg two times a day with the last dose taken at bedtime. Your doctor may reduce the dose to 100 mcg if you are sensitive to high doses.
    
    
    • Children and teenagers—Dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Cytotec

Misoprostol may cause miscarriage if taken during pregnancy. Therefore, if you suspect that you may have become pregnant, stop taking this medicine immediately and check with your doctor.

This medicine may cause diarrhea, stomach cramps, or nausea in some people. These effects will usually disappear within a few days as your body adjusts to the medicine. However, check with your doctor if the diarrhea, cramps, or nausea is severe and/or does not stop after a week. Your doctor may have to lower the dose of misoprostol you are taking.

Cytotec Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Abdominal or stomach pain (mild)


• diarrhea

Less common or rare

• Bleeding from vagina


• constipation


• cramps in lower abdomen or stomach area


• gas


• headache


• heartburn, indigestion, or acid stomach


• nausea and/or vomiting

Symptoms of overdose

• Abdominal pain


• convulsions (seizures)


• diarrhea


• drowsiness


• fast or pounding heartbeat


• fever


• low blood pressure


• slow heartbeat


• tremor


• troubled breathing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Cytotec side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Cytotec resources

• Cytotec Side Effects (in more detail)
• Cytotec Dosage
• Cytotec Use in Pregnancy & Breastfeeding
• Drug Images
• Cytotec Drug Interactions
• Cytotec Support Group
• 0 Reviews for Cytotec - Add your own review/rating

• Cytotec Prescribing Information (FDA)


• Cytotec MedFacts Consumer Leaflet (Wolters Kluwer)


• Cytotec Concise Consumer Information (Cerner Multum)


• Cytotec Monograph (AHFS DI)


• Misoprostol Prescribing Information (FDA)


• Misoprostol Professional Patient Advice (Wolters Kluwer)

Compare Cytotec with other medications

• Abortion
• Cervical Ripening
• Duodenal Ulcer
• Gynecological Conditions
• Labor Induction
• NSAID-Induced Ulcer Prophylaxis
• Postpartum Bleeding
• Stomach Ulcer

Ciprofloxacin Suspension

Pronunciation: SIP-roe-FLOX-a-sin
Generic Name: Ciprofloxacin
Brand Name: Cipro

Ciprofloxacin Suspension is associated with an increased risk of tendon problems. These include pain, swelling, inflammation, and possible breakage of tendons. The risk of tendon problems is greater in patients who are older than 60 years, patients who take corticosteroids (eg, prednisone), and in those who have received kidney, heart, or lung transplants. The Achilles tendon in the back of the foot/ankle is most often affected. However, problems may also occur in other tendons (eg, in the shoulder, arm, hand). Problems may occur while you take Ciprofloxacin Suspension or up to several months after you stop taking it.

Signs of tendon problems may include pain, soreness, redness, or swelling of a tendon or joint; bruising right after an injury in a tendon area; hearing or feeling a snap or pop in a joint or tendon area; or inability to move or bear weight on a joint or tendon area. Tell your doctor right away if you experience any of these symptoms while you take Ciprofloxacin Suspension or within several months after you stop taking it.

Ciprofloxacin Suspension may worsen muscle weakness and breathing problems in patients with myasthenia gravis. Do not take Ciprofloxacin Suspension if you have a history of myasthenia gravis.

Ciprofloxacin Suspension is used for:

Treating bacterial infections. It may also be used to prevent or slow anthrax after exposure.

Ciprofloxacin Suspension is a fluoroquinolone antibiotic. It works by killing sensitive bacteria.

Do NOT use Ciprofloxacin Suspension if:

• you are allergic to any ingredient in Ciprofloxacin Suspension or to any other fluoroquinolone (eg, levofloxacin)


• you have a history of myasthenia gravis


• you are taking tizanidine or you have recently received a live oral typhoid vaccine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Ciprofloxacin Suspension:

Some medical conditions may interact with Ciprofloxacin Suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a stomach infection, liver problems, brain or nervous system problems, increased pressure in the brain, Alzheimer disease, brain blood vessel problems, muscle problems (eg, myasthenia gravis), or a history of seizures


• if you have a history of severe or persistent diarrhea, skin sensitivity to the sun, low blood potassium levels, heart problems, or irregular heartbeat (eg, QT prolongation), or if you have a family member with a history of irregular heartbeat


• if you have a history of joint or tendon problems; rheumatoid arthritis; kidney problems or decreased kidney function; or a heart, kidney, or lung transplant


• if you take corticosteroids (eg, prednisone) or you participate in strenuous physical work or exercise

Some MEDICINES MAY INTERACT with Ciprofloxacin Suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Antiarrhythmics (eg, amiodarone, quinidine) because the risk of serious side effects, including irregular heartbeat, may be increased


• Corticosteroids (eg, prednisone) because they may increase the risk of tendon problems


• Diuretics (eg, furosemide, hydrochlorothiazide), metoclopramide, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), or probenecid because they may increase the risk of Ciprofloxacin Suspension's side effects


• Anticoagulants (eg, warfarin), antipsychotics (eg, clozapine), cyclosporine, methotrexate, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), serotonin-norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine), sulfonylureas (eg, glyburide), theophylline, tizanidine, tricyclic antidepressants (eg, amitriptyline), or xanthines (eg, caffeine) because the risk of their side effects may be increased by Ciprofloxacin Suspension


• Hydantoins (eg, phenytoin) or live oral typhoid vaccine because their effectiveness may be decreased by Ciprofloxacin Suspension

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ciprofloxacin Suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Ciprofloxacin Suspension:

Use Ciprofloxacin Suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet may be available with Ciprofloxacin Suspension. Talk to your pharmacist if you have questions about this information.


• Take Ciprofloxacin Suspension by mouth with or without food. The preferred dosing time is 2 hours after a meal.


• Shake well before each use.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• Take Ciprofloxacin Suspension with a full glass of water (8 oz/240 mL).


• Drinking extra fluids while you are taking Ciprofloxacin Suspension is recommended. Check with your doctor for instructions.


• If you also take any products containing magnesium, aluminum, calcium, iron, or zinc (eg, antacids, quinapril, vitamins/minerals); didanosine; sucralfate; or bismuth subsalicylate, do not take them within 6 hours before or 2 hours after taking Ciprofloxacin Suspension. Check with your doctor if you have questions.


• If you also take sevelamer, do not take it within 4 hours before or after taking Ciprofloxacin Suspension. Check with your doctor if you have questions.


• Ciprofloxacin Suspension works best if it is taken at the same time each day.


• To clear up your infection completely, take Ciprofloxacin Suspension for the full course of treatment. Keep taking it even if you feel better in a few days.


• Avoid taking Ciprofloxacin Suspension with milk or milk products (eg, calcium-enriched juice, yogurt) by themselves. However, taking Ciprofloxacin Suspension as part of a full meal that contains milk or milk products is permitted.


• Do not miss any doses. If you miss a dose of Ciprofloxacin Suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Ciprofloxacin Suspension.

Important safety information:

• Ciprofloxacin Suspension may cause drowsiness, dizziness, blurred vision, or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use Ciprofloxacin Suspension with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Be sure to use Ciprofloxacin Suspension for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.


• Long-term or repeated use of Ciprofloxacin Suspension may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.


• Ciprofloxacin Suspension only works against bacteria; it does not treat viral infections (eg, the common cold).


• Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate).


• Tell your doctor right away if you experience pain or swelling of a tendon or weakness or loss of use of a joint area. Rest the area and avoid exercise until further instruction from your doctor.


• Diabetes patients - Ciprofloxacin Suspension may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Ciprofloxacin Suspension may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Ciprofloxacin Suspension. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.


• Use Ciprofloxacin Suspension with caution in the ELDERLY; they may be more sensitive to its effects (eg, tendon problems), especially if they take corticosteroids (eg, prednisone). They may also be more sensitive to other effects (eg, irregular heartbeat).


• Ciprofloxacin Suspension should be used with extreme caution in CHILDREN younger than 18 years; they may be more sensitive to its effects, especially joint and tendon problems.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Ciprofloxacin Suspension while you are pregnant. Ciprofloxacin Suspension is found in breast milk. Do not breast-feed while taking Ciprofloxacin Suspension.

Possible side effects of Ciprofloxacin Suspension:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; headache; loss of appetite; nausea; stomach upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or tarry stools; burning, numbness, tingling, pain, or weakness of the arms, hands, legs, or feet; chest pain; dark urine or unusual change in the amount of urine; fainting; fever, chills, or unusual cough; hallucinations; inability to move or bear weight on a joint or tendon area; irregular heartbeat; loss of consciousness; moderate to severe sunburn; mood or mental changes (eg, new or worsening anxiety, agitation, confusion, depression, restlessness, sleeplessness); muscle pain or weakness; pain, soreness, redness, swelling, weakness, or bruising of a tendon or joint area; pale stools; persistent sore throat; red, swollen, blistered, or peeling skin; seizures; severe or persistent diarrhea; severe or persistent dizziness; shortness of breath or trouble breathing; stomach cramps or pain; suicidal thoughts or actions; tremors; unusual bruising or bleeding; unusual fatigue; vaginal yeast infection; vision changes; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Ciprofloxacin Suspension:

Store Ciprofloxacin Suspension below 86 degrees F (30 degrees C) in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Do not freeze. Throw away any unused medicine after 14 days. Keep Ciprofloxacin Suspension out of the reach of children and away from pets.

General information:

• If you have any questions about Ciprofloxacin Suspension, please talk with your doctor, pharmacist, or other health care provider.


• Ciprofloxacin Suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Ciprofloxacin Suspension. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Ciprofloxacin resources

• Ciprofloxacin Use in Pregnancy & Breastfeeding
• Drug Images
• Ciprofloxacin Drug Interactions
• Ciprofloxacin Support Group
• 89 Reviews for Ciprofloxacin - Add your own review/rating

Compare Ciprofloxacin with other medications

• Anthrax
• Anthrax Prophylaxis
• Bacteremia
• Bacterial Infection
• Bladder Infection
• Bone infection
• Bronchitis
• Chancroid
• Cholera
• Crohn's Disease
• Cutaneous Bacillus anthracis
• Diverticulitis
• Epididymitis, Sexually Transmitted
• Febrile Neutropenia
• Gonococcal Infection, Disseminated
• Gonococcal Infection, Uncomplicated
• Granuloma Inguinale
• Infection Prophylaxis
• Infectious Diarrhea
• Intraabdominal Infection
• Joint Infection
• Kidney Infections
• Meningococcal Meningitis Prophylaxis
• Mycobacterium avium-intracellulare, Treatment
• Nosocomial Pneumonia
• Peritonitis
• Plague
• Pneumonia
• Pneumonia with Cystic Fibrosis
• Prostatitis
• Rabbit Fever
• Salmonella Enteric Fever
• Salmonella Gastroenteritis
• Shigellosis
• Sinusitis
• Skin Infection
• Traveler's Diarrhea
• Tuberculosis, Active
• Typhoid Fever
• Urinary Tract Infection

Hydrochlorothiazide and candesartan

Generic Name: hydrochlorothiazide and candesartan (HYE droe KLOR oh THYE a zide and KAN de SAR tan)

Brand Names: Atacand HCT

What is hydrochlorothiazide and candesartan?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Candesartan is an angiotensin II receptor antagonists. Candesartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

The combination of hydrochlorothiazide and candesartan is used to treat high blood pressure (hypertension).

Hydrochlorothiazide and candesartan may also be used for purposes not listed in this medication guide.

What is the most important information I should know about hydrochlorothiazide and candesartan?

Do not use hydrochlorothiazide and candesartan if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. You should not use this medication if you are allergic to candesartan or hydrochlorothiazide (Carozide, Diaqua, Ezide HCTZ, HydroDiuril, Microzide, and others), or if you are unable to urinate.

Before you take this medication, tell your doctor if you have kidney or liver disease, congestive heart failure, glaucoma, low or high levels of potassium in your blood, asthma or allergies, high cholesterol or triglycerides, gout, lupus, diabetes, or an allergy to sulfa drugs or penicillin.

Hydrochlorothiazide and candesartan may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid drinking alcohol. It can lower your blood pressure and may increase some of the side effects of hydrochlorothiazide and candesartan.

What should I discuss with my healthcare provider before taking hydrochlorothiazide and candesartan?

You should not use this medication if you are allergic to candesartan or hydrochlorothiazide (Carozide, Diaqua, Ezide HCTZ, HydroDiuril, Microzide, and others), or if you are unable to urinate.

To make sure you can safely take hydrochlorothiazide and candesartan, tell your doctor if you have any of these other conditions:

• kidney disease;


• liver disease;


• 
  

  congestive heart failure;

  
  


• 
  

  glaucoma;

  
  


• 
  

  low or high levels of potassium in your blood;

  
  


• 
  

  asthma or allergies;

  
  


• 
  

  high cholesterol or triglycerides (a type of fat in the blood);

  
  


• 
  

  gout;

  
  


• 
  

  lupus;

  
  


• 
  

  diabetes; or

  
  


• 
  

  an allergy to sulfa drugs or penicillin.

  
  

FDA pregnancy category D. Do not use hydrochlorothiazide and candesartan if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. Hydrochlorothiazide and candesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking hydrochlorothiazide and candesartan. It is not known whether hydrochlorothiazide and candesartan passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take hydrochlorothiazide and candesartan?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Take this medication with a full glass (8 ounces) of water.

Your blood pressure will need to be checked often. Your blood and urine may also be tested if you have been vomiting or are dehydrated. Visit your doctor regularly.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance.

Hydrochlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using this medication.

It may take up to 4 weeks for this medication to control your blood pressure. Keep using this medication even if you feel fine. High blood pressure often has no symptoms.

If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and candesartan. You may need to stop using the medicine for a short time. Store at room temperature away from moisture and heat.

See also: Hydrochlorothiazide and candesartan dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include fast or slow heartbeat, feeling light-headed, or fainting.

What should I avoid while taking hydrochlorothiazide and candesartan?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid drinking alcohol. It can lower your blood pressure and may increase some of the side effects of hydrochlorothiazide and candesartan.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and candesartan, unless your doctor has told you to.

Hydrochlorothiazide and candesartan side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, hydrochlorothiazide and candesartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Call your doctor at once if you have any other serious side effect, such as:

• 
  

  eye pain, vision problems;

  
  


• 
  

  feeling like you might pass out;

  
  


• 
  

  chest pain, feeling short of breath, even with mild exertion;

  
  


• 
  

  fever;

  
  


• 
  

  swelling, rapid weight gain;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  jaundice (yellowing of the skin or eyes); or

  
  


• 
  

  dry mouth, increased thirst, drowsiness, restless feeling, confusion, increased urination, fast heart rate, feeling light-headed, fainting, or seizure (convulsions).

  
  

Less serious side effects may include:

• 
  

  stomach pain;

  
  


• 
  

  back pain;

  
  


• 
  

  dizziness, drowsiness;

  
  


• 
  

  headache;

  
  


• 
  

  runny or stuffy nose, sore throat; or

  
  


• 
  

  dry cough.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Hydrochlorothiazide and candesartan Dosing Information

Usual Adult Dose for Hypertension:

Initial dose: 1 tablet (16 mg-12.5 mg) orally once a day.
Maintenance dose: Once or twice daily administration with total candesartan daily doses ranging from 8 mg to 32 mg.

What other drugs will affect hydrochlorothiazide and candesartan?

Tell your doctor about all other medicines you use, especially:

• 
  

  other diuretics (water pills) or blood pressure medications;

  
  


• 
  

  steroids (prednisone and others);

  
  


• 
  

  lithium (Eskalith, Lithobid);

  
  


• 
  

  cholestyramine (Prevalite, Questran) or colestipol (Colestid);

  
  


• 
  

  insulin or diabetes medicine you take by mouth;

  
  


• 
  

  a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton);

  
  


• 
  

  aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;

  
  


• 
  

  a muscle relaxer such as baclofen (Lioresal), carisoprodol (Soma), cyclobenzaprine (Flexeril), dantrolene (Dantrium), metaxalone (Skelaxin), or methocarbamol (Robaxin), orphenadrine (Norflex), or tizanidine (Zanaflex); or

  
  


• 
  

  a narcotic medication such as hydrocodone (Lortab, Vicodin), meperidine (Demerol), methadone (Methadose), oxycodone (OxyContin), propoxyphene (Darvon, Darvocet), and others.

  
  

This list is not complete and other drugs may interact with hydrochlorothiazide and candesartan. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More hydrochlorothiazide and candesartan resources

• Hydrochlorothiazide and candesartan Side Effects (in more detail)
• Hydrochlorothiazide and candesartan Dosage
• Hydrochlorothiazide and candesartan Use in Pregnancy & Breastfeeding
• Hydrochlorothiazide and candesartan Drug Interactions
• Hydrochlorothiazide and candesartan Support Group
• 0 Reviews for Hydrochlorothiazide and candesartan - Add your own review/rating

Compare hydrochlorothiazide and candesartan with other medications

• High Blood Pressure

Where can I get more information?

• Your pharmacist can provide more information about hydrochlorothiazide and candesartan.

See also: hydrochlorothiazide and candesartan side effects (in more detail)

Chlordiazepoxide/Clidinium

Pronunciation: KLOR-dye-az-e-POX-ide/kli-DIN-ee-um
Generic Name: Chlordiazepoxide/Clidinium
Brand Name: Librax

Chlordiazepoxide/Clidinium is used for:

Treating stomach or bowel problems such as ulcers, irritability, or inflammation.

Chlordiazepoxide/Clidinium is a benzodiazepine and anticholinergic combination. It works by relieving anxiety and reducing digestive secretions. This helps to improve certain stomach or bowel conditions.

Do NOT use Chlordiazepoxide/Clidinium if:

• you are allergic to any ingredient in Chlordiazepoxide/Clidinium


• you have problems swallowing, or other severe esophagus problems (eg, inflammation, reflux)


• you have severe stomach or bowel problems (eg, blockage, inflammation, loss of muscle tone)


• you have a blockage of your bladder, an enlarged prostate, glaucoma, myasthenia gravis, or severe liver problems


• you have severe mental problems (eg, psychosis)


• you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Chlordiazepoxide/Clidinium:

Some medical conditions may interact with Chlordiazepoxide/Clidinium. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have kidney or liver problems


• if you have problems urinating


• if you have a history of blood problems (eg, porphyria), glaucoma, increased pressure in the eye, or abnormal electroencephalograms (EEGs)


• if you have a history of heart problems (eg, irregular heartbeat, congestive heart failure), hernia, lung or breathing problems (eg, chronic obstructive pulmonary disease [COPD]), or nerve and muscle problems


• if you have a history of mood or mental problems (eg, anxiety, depression), suicidal thoughts or actions, or a history of alcohol or other substance dependence or abuse


• if you have been very ill

Some MEDICINES MAY INTERACT with Chlordiazepoxide/Clidinium. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Clozapine, methadone, or sodium oxybate (GHB) because delirium, severe drowsiness, severe breathing problems, or serious low blood pressure may occur


• Anticoagulants (eg, warfarin) because changes in blood clotting may occur


• Azole antifungals (eg, ketoconazole), disulfiram, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), nefazodone, omeprazole, or phenothiazines (eg, thioridazine) because they may increase the risk of Chlordiazepoxide/Clidinium's side effects


• Rifampin because it may decrease Chlordiazepoxide/Clidinium's effectiveness


• Hydantoins (eg, phenytoin) because the risk of their side effects may be increased by Chlordiazepoxide/Clidinium

This may not be a complete list of all interactions that may occur. Ask your health care provider if Chlordiazepoxide/Clidinium may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Chlordiazepoxide/Clidinium:

Use Chlordiazepoxide/Clidinium as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Chlordiazepoxide/Clidinium by mouth before meals and at bedtime, unless otherwise directed by your doctor.


• If you miss a dose of Chlordiazepoxide/Clidinium, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Chlordiazepoxide/Clidinium.

Important safety information:

• Chlordiazepoxide/Clidinium may cause drowsiness. This effect may be worse if you take it with alcohol or certain medicines. Use Chlordiazepoxide/Clidinium with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Chlordiazepoxide/Clidinium; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Lab tests, including liver function and complete blood cell counts, may be performed while you use Chlordiazepoxide/Clidinium. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Chlordiazepoxide/Clidinium with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion, drowsiness, and loss of coordination.


• Chlordiazepoxide/Clidinium should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Chlordiazepoxide/Clidinium may cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Chlordiazepoxide/Clidinium while you are pregnant. Chlordiazepoxide/Clidinium is found in breast milk. Do not breast-feed while taking Chlordiazepoxide/Clidinium.

Some people who use Chlordiazepoxide/Clidinium for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction.

If you stop taking Chlordiazepoxide/Clidinium suddenly, you may have WITHDRAWAL symptoms. These may include unpleasant feelings. In more severe cases, you may have stomach and muscle cramps, vomiting, sweating, and shakiness. Seizures may rarely occur. If you take Chlordiazepoxide/Clidinium for more than 1 to 2 weeks, do not stop taking it without talking to your doctor.

Possible side effects of Chlordiazepoxide/Clidinium:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; constipation; drowsiness; dry mouth.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); behavior changes (eg, excessive anger or rage); changes in sexual desire; changes in the menstrual period; confusion; difficulty urinating; excitability; fainting; loss of coordination; sore throat or fever; swelling; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Chlordiazepoxide/Clidinium side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; extreme drowsiness; loss of consciousness; slowed reflexes.

Proper storage of Chlordiazepoxide/Clidinium:

Store Chlordiazepoxide/Clidinium at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Keep Chlordiazepoxide/Clidinium out of the reach of children and away from pets.

General information:

• If you have any questions about Chlordiazepoxide/Clidinium, please talk with your doctor, pharmacist, or other health care provider.


• Chlordiazepoxide/Clidinium is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Chlordiazepoxide/Clidinium. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Chlordiazepoxide/Clidinium resources

• Chlordiazepoxide/Clidinium Side Effects (in more detail)
• Chlordiazepoxide/Clidinium Dosage
• Chlordiazepoxide/Clidinium Use in Pregnancy & Breastfeeding
• Drug Images
• Chlordiazepoxide/Clidinium Drug Interactions
• Chlordiazepoxide/Clidinium Support Group
• 14 Reviews for Chlordiazepoxide/Clidinium - Add your own review/rating

Compare Chlordiazepoxide/Clidinium with other medications

• Enterocolitis
• Irritable Bowel Syndrome
• Peptic Ulcer

Hylorel

Generic Name: guanadrel (GWAH na drel)

Brand Names: Hylorel

What is Hylorel (guanadrel)?

Guanadrel lowers blood pressure by decreasing the levels of certain chemicals in the blood. This allows the blood vessels (veins and arteries) to relax (widen).

Guanadrel is used to treat hypertension (high blood pressure).

Guanadrel may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Hylorel (guanadrel)?

Do not stop taking guanadrel suddenly without first talking to your doctor. This could cause severely high blood pressure, nervousness, and anxiety. Use caution when driving, operating machinery, or performing other hazardous activities. Guanadrel may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use caution when rising from a sitting or lying position, especially first thing in the morning. Dizziness may occur while taking guanadrel and may result in a fall.

What should I discuss with my healthcare provider before taking Hylorel (guanadrel)?

Do not take guanadrel without first talking to your doctor if you

• 
  

  have congestive heart failure;

  
  


• 
  

  have pheochromocytoma; or

  
  


• 
  

  are taking a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate).

  
  

Before taking this medication, tell your doctor if you have

• 
  

  peptic ulcer disease (stomach ulcers);

  
  


• 
  

  ulcerative colitis;

  
  


• kidney disease; or


• 
  

  asthma.

  
  

You may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Guanadrel is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take guanadrel without first talking to your doctor if you are pregnant or could become pregnant during treatment. Guanadrel passes into breast milk and it may be harmful to a nursing infant. Do not take guanadrel without first talking to your doctor if you are breast-feeding a baby.

How should I take Hylorel (guanadrel)?

Take guanadrel exactly as directed. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Take guanadrel with food or milk if it causes stomach upset.

It is important to take guanadrel regularly to get the most benefit.

Do not stop taking guanadrel suddenly without first talking to your doctor. This could cause severely high blood pressure, nervousness, and anxiety.

Your doctor may want you to have blood pressure monitoring or other medical evaluations during treatment with guanadrel to monitor progress and side effects.

Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention if an overdose is suspected.

Symptoms of a guanadrel overdose include low blood pressure (fainting, dizziness, weakness); a slow pulse; low body temperature; diarrhea; and slow breathing.

What should I avoid while taking Hylorel (guanadrel)?

Use caution when driving, operating machinery, or performing other hazardous activities. Guanadrel may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use caution when rising from a sitting or lying position, especially first thing in the morning. Dizziness may occur while taking guanadrel and may result in a fall.

Avoid alcohol while taking guanadrel. It may increase drowsiness an dizziness caused by guanadrel. Use caution even with small amounts of alcohol.

Guanadrel may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if guanadrel is taken with any of these medications. Tell your doctor about all medicines that you are taking, and do not take any medicine without first talking to your doctor.

Avoid becoming overheated in hot weather or during exercise. Also avoid standing for long periods of time and use caution if you have a fever. These situations increase the effects of guanadrel in the body and may cause dizziness.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Hylorel (guanadrel) side effects

If you experience any of the following serious side effects, stop taking guanadrel and seek emergency medical attention or contact your doctor immediately:

• 
  

  an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

  
  


• 
  

  irregular heartbeats;

  
  


• 
  

  heart failure (shortness of breath, swelling of ankles or legs, sudden weight gain of 5 pounds or more); or

  
  


• 
  

  chest pain.

  
  

Other, less serious side effects are more likely to occur. Continue to take guanadrel and talk to your doctor if you experience

• 
  

  unusual fatigue or drowsiness;

  
  


• 
  

  dizziness (avoid standing up to quickly and use caution when performing hazardous activities);

  
  


• 
  

  anxiety, depression, or nightmares;

  
  


• 
  

  diarrhea, nausea, or vomiting (take guanadrel with food or milk if it upsets your stomach);

  
  


• 
  

  a stuffy nose or a dry mouth (sucking on ice chips or sugarless hard candy may relieve a dry mouth);

  
  


• 
  

  blurred vision;

  
  


• 
  

  weight gain; or

  
  


• impotence or difficulty ejaculating.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Hylorel (guanadrel)?

Do not take guanadrel without first talking to your doctor if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days

Before taking guanadrel, tell your doctor if you are taking any of the following medicines:

• 
  

  a respiratory medicine such as albuterol (Ventolin, Proventil, Volmax, others), pirbuterol (Maxair), salmeterol (Serevent), and others;

  
  


• 
  

  a beta-blocker such as atenolol (Tenormin), acebutolol (Sectral), bisoprolol (Zebeta), carteolol (Cartrol), carvedilol (Coreg), labetalol (Trandate, Normodyne), metoprolol (Lopressor), nadolol (Corgard), propranolol (Inderal), pindolol (Visken), and timolol (Blocadren);

  
  


• 
  

  a phenothiazine such as chlorpromazine (Thorazine), prochlorperazine (Compazine), perphenazine (Trilafon), fluphenazine (Prolixin), thioridazine (Mellaril), and others;

  
  


• 
  

  other heart medications such as hydralazine (Apresoline) or minoxidil (Loniten); or

  
  


• 
  

  a tricyclic antidepressant such as amitriptyline (Elavil, Endep), imipramine (Tofranil), doxepin (Sinequan), nortriptyline (Pamelor), and others.

  
  

You may require special monitoring or a dosage adjustment if you are taking any of the medicines listed above.

Guanadrel may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine without first talking to your doctor.

Drugs other than those listed here may also interact with guanadrel or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

More Hylorel resources

• Hylorel Side Effects (in more detail)
• Hylorel Use in Pregnancy & Breastfeeding
• Hylorel Drug Interactions
• Hylorel Support Group
• 0 Reviews for Hylorel - Add your own review/rating

• Hylorel Advanced Consumer (Micromedex) - Includes Dosage Information


• Guanadrel Professional Patient Advice (Wolters Kluwer)

Compare Hylorel with other medications

• High Blood Pressure

Where can I get more information?

• Your pharmacist has additional information about guanadrel written for health professionals that you may read.

What does my medication look like?

Guanadrel is available with a prescription under the brand name Hylorel. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• 
  

  Hylorel 10 mg--light-orange, elliptical, scored tablets

  
  


• 
  

  Hylorel 25 mg--white, elliptical, scored tablets

  
  

See also: Hylorel side effects (in more detail)